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Ascenta Therapeutics announced positive preliminary results from its Phase II study of AT-101 in combination with docetaxel and prednisone (D/P) in men with docetaxel refractory, castrate resistant prostate cancer (CRPC) at the American Society of Clinical Oncology (ASCO) Genitourinary Cancers Symposium in Orlando, FL. AT-101, an oral, pan-Bcl-2 inhibitor currently in double-blinded, randomized Phase II [...]

Long-term use of beta carotene and some other carotenoid-containing dietary supplements may increase the risk of lung cancer, especially among smokers, according to a study by University of North Carolina at Chapel Hill researchers. The study, which also examined use of retinol, vitamin A, lycopene and lutein, appears in the February issue of the American [...]

Women who’ve had a breast biopsy know the anxiety of waiting for the results, but that stress may cause adverse health effects, according to a new study published in the March issue of Radiology. “When women express how taxing it is to have to wait for results, the medical establishment may dismiss their feelings as [...]

Goserelin, a lutenizing hormone-releasing hormone agonist, reduces the long-term risk of disease recurrence and deaths in premenopausal women with early breast cancer who did not take tamoxifen, according to trial data reported in the February 24 online issue of the Journal of the National Cancer Institute. Systematic reviews have shown that lutenizing hormone-releasing hormone agonists, [...]

An article in The Lancet Oncology’s February issue reports that a breast cancer patient´s risk of recurrence increases considerably with the use of Tibolone, a synthetic steroid used in preventing osteoporosis and treating menopausal symptoms. As a result, breast cancer survivors and current patients should not be givenTibolone. Early menopause is frequently a result of [...]

A novel compound in development by AstraZeneca as an oral tablet for hormone resistant prostate cancer (HRPC), ZD4054, could improve overall survival (OS) in men with metastatic HRPC, according to Phase II data published today in European Urology.[1] Men with advanced prostate cancer may receive initially effective treatment with hormonal therapies to which the majority [...]

US scientists reviewing 20 years of research and expert opinion on generic versus brand name drugs in the treatment of cardiovascular diseases found no clinical evidence showing brand names were superior to generic versions even though a substantial number of experts writing editorials advised against interchanging them. The study was the work of Dr Aaron [...]

Thirteen of the 20 cities in which a clinical trial was conducted for an artificial blood substitute had minority populations greater than that of the nation as a whole, according to records obtained by the Detroit Free Press. The blood substitute Polyheme, manufactured by Northfield Laboratories, is made by extracting hemoglobin from human red blood [...]

Early clinical trials “tend to enroll relatively healthy white males but few children, women, minorities and older patients” — a disparity that can result in research that “ignores biological differences that cause people of varying ages, genders and ethnicities to react differently to therapies,” the Baltimore Sun reports. According to the Sun, “therapies that perform [...]

Several vaccine trials are being postponed or modified following the halt of Merck’s experimental HIV vaccine trial, the Philadelphia Inquirer reports (Stark, Philadelphia Inquirer, 11/16). Merck in September announced that it had ended the Phase II trial, which began in late 2004 and involved HIV-negative volunteers, after the experimental vaccine failed to prevent HIV infection [...]