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Researchers funded by the Canadian Cancer Society have discovered eight similar genes that, when mutated, appear to be responsible for medulloblastoma – the most common of childhood brain cancers. The findings are published in the online edition of the journal Nature Genetics. “This discovery is very promising and may help researchers develop better, more targeted [...]

Giving patients with glioblastoma-the most common and aggressive form of primary brain tumour-the chemotherapy drug temozolomide in combination with radiotherapy increases their survival compared with those receiving radiotherapy alone and this improvement persists for up to 5 years, according to the final results of the EORTC-NCIC trial*, published Online first and in the May edition [...]

The combination of two drugs produces a critical improvement in the treatment of certain brain tumours. This has been demonstrated by researchers at Bonn University working in co-operation with German and Swiss colleagues in a current study. They treated 39 patients who had been diagnosed with a so-called gliablastoma. The patients survived on average 23 [...]

Schering-Plough Corporation (NYSE: SGP) announced that the European Commission and the US FDA both approved the intravenous (IV) formulation of temozolomide as an alternative to the already approved oral form of the drug. Temozolomide is marketed as TEMODAL(R) in the EU and as TEMODAR(R) in the US. The EU Commission Decision was based on the [...]

While surviving cancer should be an occasion for rejoicing, many people who have undergone the standard or high-dose chemotherapy to defeat the disease unfortunately suffer from a physical and mental ailment known as “chemobrain.” This cognitively dysfunctional symptom ranges from fatigue and memory loss to serious learning impairment due to possible brain damage. In CHEMOBRAIN: [...]

People in the Northeastern U.S. are one-third more likely than those in the South or West to be hospitalized for treatment of brain cancer or to have brain cancer when they are hospitalized for another illness or complication, according to the latest News and Numbers from the U.S. Agency for Healthcare Research and Quality. In [...]

Cognitive neuroscientists at the Swedish medical university Karolinska Institutet (KI) have succeeded in making subjects perceive the bodies of mannequins and other people as their own. The findings are published in the online, open-access journal PLoS ONE, December 3. In the first experiment, the head of a shop dummy was fitted with two cameras connected [...]

Most children are able to imagine their future selves as astronauts, politicians or even superheroes; however, many older adults find it difficult to recollect past events, let alone generate new ones. A new Harvard University study reveals that the ability of older adults to form imaginary scenarios is linked to their ability to recall detailed [...]

New research at Wake Forest University Baptist Medical Center suggests that a three-drug cocktail may one day improve outcomes in patients with glioblastoma multiforme (GBM), a type of brain tumor with a dismal prognosis. Two of the drug candidates have been developed, and the team is working on the third all targeted to kill or [...]

1. Neuron, Astrocyte, and Oligodendrocyte Transcriptomes John D. Cahoy, Ben Emery, Amit Kaushal, Lynette C. Foo, Jennifer L. Zamanian, Karen S. Christopherson, Yi Xing, Jane L. Lubischer, Paul A. Krieg, Sergey A. Krupenko, Wesley J. Thompson, and Ben A. Barres In this issue, Cahoy et al. describe a comprehensive database of quantitative gene expression data [...]